Sharma M, Srinivasan V T, Singh B B
Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Trombay, Bombay, India.
Int J Hyperthermia. 1993 Nov-Dec;9(6):811-9. doi: 10.3109/02656739309034984.
In vitro studies on Swiss mice, inoculated with dead or live sarcoma 180-A ascites cells, were carried out to monitor the changes, if any, in the longitudinal (T1) and transverse (T2) relaxation times of tissue water protons following hyperthermic treatment and subsequent thermotolerance. Both relaxation processes exhibited biexponential relaxation curves. With increasing size of the tumours, the longitudinal relaxation behaviour changed from bi- to mono-exponential. This was not observed for the transverse relaxation phenomenon. Inoculation with either dead or live cells caused an immediate increase in the both relaxation times. In the case of dead cell inoculation, the increase lasted for only 24 h after which the relaxation times became the same as for the uninoculated controls. The transverse relaxation time increased as a result of exposure to hyperthermia. During development of thermotolerance, both the relaxation times decreased.
对接种了死的或活的肉瘤180 - A腹水细胞的瑞士小鼠进行了体外研究，以监测热疗及随后的热耐受后组织水质子纵向（T1）和横向（T2）弛豫时间的变化（若有）。两个弛豫过程均呈现双指数弛豫曲线。随着肿瘤尺寸的增加，纵向弛豫行为从双指数变为单指数。横向弛豫现象未观察到这种情况。接种死细胞或活细胞均导致两个弛豫时间立即增加。在接种死细胞的情况下，增加仅持续24小时，之后弛豫时间变得与未接种对照相同。横向弛豫时间因热暴露而增加。在热耐受形成过程中，两个弛豫时间均下降。
