Moriya T, Shinoda T, Kannou Y, Nakajima K, Takeda T, Takasu N, Aizawa T, Yamada T, Hataya Y, Itoh N
Department of Internal Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Nihon Jinzo Gakkai Shi. 1994 Jan;36(1):69-75.
We report a 49-year-old Japanese male with nephrotic syndrome associated with Kimura's disease. Renal biopsy revealed diffuse podocytic detachment from the glomerular basement membrane (GBM). He had an episode of nephrotic syndrome when complete remission was induced with steroid therapy six years prior to the present admission. However, complete remission of the nephrotic syndrome was not achieved by the steroid on this admission and massive proteinuria (5 g/day) persisted. We suggest that steroid-resistant proteinuria is closely related to podocytic detachment from the GBM and that the production of extracellular matrix by epithelial cells may participate in segmental sclerotic lesions in the patient.
我们报告了一名49岁的日本男性，患有与木村病相关的肾病综合征。肾活检显示肾小球足细胞从肾小球基底膜（GBM）弥漫性脱离。他在本次入院前六年接受类固醇治疗诱导完全缓解时曾有一次肾病综合征发作。然而，此次入院时类固醇治疗未能使肾病综合征完全缓解，大量蛋白尿（5克/天）持续存在。我们认为类固醇抵抗性蛋白尿与足细胞从GBM脱离密切相关，并且上皮细胞产生细胞外基质可能参与了该患者的节段性硬化病变。
