Cardozo L, Rekers H, Tapp A, Barnick C, Shepherd A, Schussler B, Kerr-Wilson R, van Geelan J, Barlebo H, Walter S
Department of Obstetrics and Gynecology, King's College Hospital, London, UK.
Maturitas. 1993 Dec;18(1):47-53. doi: 10.1016/0378-5122(93)90028-g.
Oestrogen deficiency in postmenopausal women is thought to be important in the genesis of lower urinary tract symptoms, in particular the 'urge syndrome'. Evidence to support the use of oestrogen therapy in symptomatic postmenopausal women is, however, limited. Oestriol is a weak, naturally occurring oestrogen that may be beneficial to the urogenital tissues without stimulating the endometrium. We have investigated the use of oestriol in the treatment of postmenopausal sensory and motor urge incontinence.
A double-blind, placebo-controlled, randomised, multicentre study of 3 mg oral oestriol/day for 3 months in the treatment of women with urge incontinence was undertaken.
Sixty-four women were recruited into the study. Although oestriol produced both subjective and objective improvement in lower urinary tract function, it was not significantly better than placebo. Some of the difficulties of running a multicentre study were encountered.
绝经后女性的雌激素缺乏被认为在下尿路症状的发生中起重要作用，尤其是“尿急综合征”。然而，支持有症状的绝经后女性使用雌激素治疗的证据有限。雌三醇是一种弱的天然雌激素，可能对泌尿生殖组织有益而不刺激子宫内膜。我们研究了雌三醇在治疗绝经后感觉性和运动性尿急失禁中的应用。
进行了一项双盲、安慰剂对照、随机、多中心研究，给予每日3毫克口服雌三醇，持续3个月，用于治疗尿急失禁女性。
64名女性被纳入该研究。尽管雌三醇在主观和客观上都改善了下尿路功能，但并不比安慰剂有显著更好的效果。遇到了开展多中心研究的一些困难。
