阴道加德纳菌的抗菌药敏性
Antimicrobial susceptibilities of Gardnerella vaginalis.
作者信息
Kharsany A B, Hoosen A A, Van den Ende J
机构信息
Department of Medical Microbiology, Faculty of Medicine, University of Natal, Durban, South Africa.
出版信息
Antimicrob Agents Chemother. 1993 Dec;37(12):2733-5. doi: 10.1128/AAC.37.12.2733.
Abstract
The in vitro susceptibilities of 93 clinical isolates of Gardnerella vaginalis to 25 antimicrobial agents were determined by the agar dilution method. All isolates were susceptible to penicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, and trimethoprim. Activity was poor for vancomycin, LY146032, the cephalosporins, ciprofloxacin, and imipenem. Some resistance was observed with tetracycline and minocycline. The MICs of metronidazole paralleled those of tinidazole, with the hydroxymetabolite of metronidazole being the most active. One strain was resistant to all three agents. Marked resistance to aztreonam, amikacin, and sulfamethoxazole was observed.
摘要
采用琼脂稀释法测定了93株阴道加德纳菌临床分离株对25种抗菌药物的体外敏感性。所有分离株对青霉素、氨苄西林、红霉素、克林霉素、氯霉素和甲氧苄啶敏感。万古霉素、LY146032、头孢菌素、环丙沙星和亚胺培南的活性较差。四环素和米诺环素存在一定耐药性。甲硝唑的最低抑菌浓度与替硝唑相似，甲硝唑的羟基代谢产物活性最强。有1株对这3种药物均耐药。对氨曲南、阿米卡星和磺胺甲恶唑表现出明显耐药。
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