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一些味觉物质是G蛋白的直接激活剂。

Some taste substances are direct activators of G-proteins.

作者信息

Naim M, Seifert R, Nürnberg B, Grünbaum L, Schultz G

机构信息

Institut für Pharmakologie, Freie Universität Berlin, Federal Republic of Germany.

出版信息

Biochem J. 1994 Feb 1;297 ( Pt 3)(Pt 3):451-4. doi: 10.1042/bj2970451.

DOI:10.1042/bj2970451
PMID:8110180
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1137854/
Abstract

Amphiphilic substances may stimulate cellular events through direct activation of G-proteins. The present experiments indicate that several amphiphilic sweeteners and the bitter tastant, quinine, activate transducin and Gi/Go-proteins. Concentrations of taste substances required to activate G-proteins in vitro correlated with those used to elicit taste. These data support the hypothesis that amphiphilic taste substances may elicit taste through direct activation of G-proteins.

摘要

两亲性物质可通过直接激活G蛋白来刺激细胞活动。目前的实验表明，几种两亲性甜味剂和苦味剂奎宁可激活转导素以及Gi/Go蛋白。体外激活G蛋白所需的味觉物质浓度与引发味觉所用的浓度相关。这些数据支持了两亲性味觉物质可能通过直接激活G蛋白来引发味觉的假说。

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