Theisinger B, Guthke R, Blin N, Welter C, Seitz G
Institute of Human Genetics, Univ. d. Saarlandes, Homburg, Germany.
In Vivo. 1993 Sep-Oct;7(5):411-4.
The biological function of the hormone inducible human pS2/BCEI gene, cloned from the breast cancer cell line MCF-7, still remains unknown. Our aim was to determine the in vivo influence of steroid hormones on pS2 expression and tumour growth in colorectal tumours. We transplanted aliquots of human colon tumours into male and female nude mice and studied tumour growth and expression of the pS2/BCEI gene by immunostaining and mRNA analysis. Our results show that the sex of the host and therefore the hormonal background does not play a dominant role in pS2 expression and growth of the xenografts.
从乳腺癌细胞系MCF-7克隆出的激素诱导型人pS2/BCEI基因的生物学功能仍不清楚。我们的目的是确定类固醇激素对结直肠肿瘤中pS2表达和肿瘤生长的体内影响。我们将人结肠肿瘤的等分试样移植到雄性和雌性裸鼠体内，并通过免疫染色和mRNA分析研究肿瘤生长及pS2/BCEI基因的表达。我们的结果表明，宿主的性别以及因此产生的激素背景在异种移植物的pS2表达和生长中并不起主导作用。
