人类重组激活基因1（RAG1）定位于染色体11p13的确认。
Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13.
作者信息
Schwarz K, Hameister H, Gessler M, Grzeschik K H, Hansen-Hagge T E, Bartram C R
机构信息
Sektion Molekularbiologie, Universität Ulm, Germany.
出版信息
Hum Genet. 1994 Feb;93(2):215-7. doi: 10.1007/BF00210617.
The human recombination activating gene 1 (RAG1) has previously been mapped to chromosomes 14q and 11p. Here we confirm the chromosome 11 assignment by two independent approaches: autoradiographic and fluorescence in situ hybridization to metaphase spreads and analysis of human-hamster somatic cell hybrid DNA by the polymerase chain reaction (PCR) and Southern blotting. Our results unequivocally localize RAG1 to 11p13.
人类重组激活基因1（RAG1）先前已被定位到14号染色体长臂和11号染色体短臂。在此，我们通过两种独立的方法证实了其在11号染色体上的定位：对中期染色体进行放射自显影和荧光原位杂交，以及通过聚合酶链反应（PCR）和Southern印迹法分析人-仓鼠体细胞杂种DNA。我们的结果明确地将RAG1定位到11p13。
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