Imai M, Iijima H
Department of Ophthalmology, Yamanashi Medical College, Japan.
Jpn J Ophthalmol. 1995;39(3):254-9.
Using precise experimental methods, we evaluated the recovery from pressure-induced ischemia in rabbit retina using photopic electroretinography (ERG). The recovery was evaluated and documented in terms of the increasing amplitude and the decreasing delay of implicit time in the photopic ERG after inducing 30-, 60- and 90-minute ischemia. A ganzfeld dome was utilized to stimulate both the experimental and the control fellow eye. The changes in ERG parameters in the ischemic eye were assessed by comparison with the values simultaneously obtained in the fellow eye, which could minimize the effect of anesthesia. One hour after reperfusion, the implicit time returned to almost the same value as that in the fellow eye in eyes with 30-minute ischemia, while it showed significant delay in eyes with 60-minute ischemia. The amplitude was smaller than that in the fellow eye in eyes with both 30- and 60-minute ischemia. Photopic ERG was not recorded one hour after reperfusion in more than half the eyes with 90-minute ischemia.
我们采用精确的实验方法，运用明视视网膜电图（ERG）评估了兔视网膜压力诱导性缺血后的恢复情况。在诱导30分钟、60分钟和90分钟缺血后，根据明视ERG中振幅增加和隐时延迟减少的情况对恢复情况进行评估和记录。使用全视野球罩刺激实验眼和对照侧眼。通过与对照侧眼同时获得的值进行比较，评估缺血眼ERG参数的变化，这可以将麻醉的影响降至最低。再灌注1小时后，30分钟缺血组的隐时恢复到与对照侧眼几乎相同的值，而60分钟缺血组的隐时则出现明显延迟。30分钟和60分钟缺血组的振幅均低于对照侧眼。超过一半的90分钟缺血组在再灌注1小时后未记录到明视ERG。
