Kimitsuki T, Nakagawa T, Hisashi K, Komune S, Komiyama S
Department of Otorhinolaryngology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hear Res. 1993 Dec;71(1-2):64-8. doi: 10.1016/0378-5955(93)90021-r.
The effects of cisplatin (cis-dichlorodiammine platinum II, CDDP) on the mechano-electrical transduction (MET) current were investigated with a whole-cell patch-electrode voltage clamp technique in dissociated cochlear hair cells of chicks. CDDP blocked the MET channel in a dose- and voltage-dependent manner. At -50 mV, CDDP blocked the MET channel with a Hill coefficient of approximately 2 and a dissociation constant (KD) of 1.5 x 10(-3) M. The kinetics of CDDP blockade consist of a voltage-independent and a voltage-dependent component.
