眼表上皮发育异常发生的危险因素。

Risk factors in the development of ocular surface epithelial dysplasia.

作者信息

Lee G A, Williams G, Hirst L W, Green A C

机构信息

Department of Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.

出版信息

Ophthalmology. 1994 Feb;101(2):360-4. doi: 10.1016/s0161-6420(94)31328-5.

DOI:10.1016/s0161-6420(94)31328-5

PMID:8115157

Abstract

BACKGROUND

Ocular surface epithelial dysplasia involves a spectrum of diseases ranging from only minor eye irritation to blindness and potentially death.

METHODS

A case-control study involving 60 patients with ocular surface epithelial dysplasia treated between 1972 and 1991 and 60 age- and sex-matched individuals was conducted to compare relative ultraviolet light exposures over their lifetimes. A standardized self-administered ultraviolet exposure questionnaire was used for assessment.

RESULTS

Risk factors identified include phenotypic features such as fair skin (odds ratio [OR], 5.4; 95% confidence interval [CI], 1.1, 25.6), pale iris (OR, 1.8; 95%; CI, 0.9, 3.8), and propensity to sunburn (OR, 3.8; 95% CI, 0.7, 19.7), history of previous skin cancers removed (OR, 15; 95% CI, 2.0, 113.6), and being outdoors more than 50% of time in the first 6 years of life while living 30 degrees or less from the equator (OR, 7.5; 95% CI, 1.8, 30.6).

CONCLUSION

These risk factors suggest that ocular surface epithelial dysplasia is an ultraviolet light-related disease.

摘要

背景

眼表上皮发育异常涉及一系列疾病，从轻微的眼部刺激到失明甚至可能死亡。

方法

开展一项病例对照研究，纳入1972年至1991年间接受治疗的60例眼表上皮发育异常患者以及60例年龄和性别匹配的个体，比较他们一生中紫外线暴露情况。使用标准化的自我管理紫外线暴露问卷进行评估。

结果

确定的危险因素包括表型特征，如白皙皮肤（比值比[OR]，5.4；95%置信区间[CI]，1.1，25.6）、浅色虹膜（OR，1.8；95%CI，0.9，3.8）和晒伤倾向（OR，3.8；95%CI，0.7，19.7），既往切除皮肤癌病史（OR，15；95%CI，2.0，113.6），以及在生命的前6年中，当居住在距离赤道30度或更小范围内时，超过50%的时间在户外（OR，7.5；95%CI，1.8，30.6）。