Lee G A, Williams G, Hirst L W, Green A C
Department of Surgery, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
Ophthalmology. 1994 Feb;101(2):360-4. doi: 10.1016/s0161-6420(94)31328-5.
Ocular surface epithelial dysplasia involves a spectrum of diseases ranging from only minor eye irritation to blindness and potentially death.
A case-control study involving 60 patients with ocular surface epithelial dysplasia treated between 1972 and 1991 and 60 age- and sex-matched individuals was conducted to compare relative ultraviolet light exposures over their lifetimes. A standardized self-administered ultraviolet exposure questionnaire was used for assessment.
Risk factors identified include phenotypic features such as fair skin (odds ratio [OR], 5.4; 95% confidence interval [CI], 1.1, 25.6), pale iris (OR, 1.8; 95%; CI, 0.9, 3.8), and propensity to sunburn (OR, 3.8; 95% CI, 0.7, 19.7), history of previous skin cancers removed (OR, 15; 95% CI, 2.0, 113.6), and being outdoors more than 50% of time in the first 6 years of life while living 30 degrees or less from the equator (OR, 7.5; 95% CI, 1.8, 30.6).
These risk factors suggest that ocular surface epithelial dysplasia is an ultraviolet light-related disease.
眼表上皮发育异常涉及一系列疾病，从轻微的眼部刺激到失明甚至可能死亡。
开展一项病例对照研究，纳入1972年至1991年间接受治疗的60例眼表上皮发育异常患者以及60例年龄和性别匹配的个体，比较他们一生中紫外线暴露情况。使用标准化的自我管理紫外线暴露问卷进行评估。
确定的危险因素包括表型特征，如白皙皮肤（比值比[OR]，5.4；95%置信区间[CI]，1.1，25.6）、浅色虹膜（OR，1.8；95%CI，0.9，3.8）和晒伤倾向（OR，3.8；95%CI，0.7，19.7），既往切除皮肤癌病史（OR，15；95%CI，2.0，113.6），以及在生命的前6年中，当居住在距离赤道30度或更小范围内时，超过50%的时间在户外（OR，7.5；95%CI，1.8，30.6）。
这些危险因素表明眼表上皮发育异常是一种与紫外线相关的疾病。
