White R H, Becker D M, Gunther-Maher M G
Department of Internal Medicine, University of California, Davis Medical Center, Sacramento.
South Med J. 1994 Feb;87(2):206-10. doi: 10.1097/00007611-199402000-00012.
We review our collective experience over the past 4 years using a portable instrument that measures the International Normalized Ratio (INR) and the prothrombin time (PT). The device can be used readily in ambulatory clinic settings and by patients in their homes. The major advantage of the monitor is that the INR/PT can be measured quickly; if a change in the dose of warfarin is necessary, instructions can be discussed directly with the patient at the time of the visit. Compared with clinical laboratory determinations, monitor INRs are quite accurate, with approximately 85% of measurements within 0.9 INR units of the corresponding laboratory value. If necessary, monitor INRs can be adjusted to approximate a specific clinical laboratory's INRs with a regression formula derived from analysis of duplicate INRs using the monitor and the laboratory. Although the Food and Drug Administration has not yet approved use of the monitor by patients at home, use of a portable measuring device in the home by home health agencies may be valuable in selected cases.
我们回顾了过去4年使用一种便携式仪器测量国际标准化比值（INR）和凝血酶原时间（PT）的总体经验。该设备可轻松用于门诊诊所环境以及患者家中。该监测仪的主要优点是可以快速测量INR/PT；如果需要调整华法林剂量，可在就诊时直接与患者讨论用药说明。与临床实验室检测结果相比，监测仪测得的INR相当准确，约85%的测量值与相应实验室值的INR单位相差在0.9以内。如有必要，可使用通过对监测仪和实验室的重复INR分析得出的回归公式，将监测仪测得的INR调整为接近特定临床实验室的INR。尽管美国食品药品监督管理局尚未批准患者在家中使用该监测仪，但在某些特定情况下，家庭健康机构让患者在家中使用便携式测量设备可能会有帮助。
