Favaloro Emmanuel J
Haematology Department, Sydney Centres for Thrombosis and Haemostasis, Institute of Clinical Pathology and Medical Research (ICPMR), Westmead Hospital, NSW Health Pathology, Westmead, NSW, 2145, Australia.
Methods Mol Biol. 2017;1646:59-74. doi: 10.1007/978-1-4939-7196-1_4.
The Prothrombin Time (PT) assay is the most common test performed in hemostasis laboratories, most commonly as converted to an international normalized ratio (INR) to monitor anticoagulant therapy using vitamin K antagonists (VKAs) such as warfarin. Although the INR is meant to standardize PT values by taking into consideration reagent and instrument variability, substantial inter-laboratory variation in INRs still exists and suggests that this can be further improved. This paper describes the PT test, its conversion to an INR value, and methods to improve the accuracy of INRs by improving the determination of critical components to the INR, namely the mean normal prothrombin time (MNPT) and the international sensitive index (ISI).
凝血酶原时间（PT）测定是止血实验室最常进行的检测，最常见的是将其转换为国际标准化比值（INR），以监测使用维生素K拮抗剂（VKA）如华法林的抗凝治疗。尽管INR旨在通过考虑试剂和仪器的变异性来标准化PT值，但实验室间INR仍存在显著差异，这表明仍有进一步改进的空间。本文介绍了PT检测、其转换为INR值的方法，以及通过改进INR关键成分（即平均正常凝血酶原时间（MNPT）和国际敏感指数（ISI））的测定来提高INR准确性的方法。
