Langkilde A M, Andersson H, Bosaeus I
Dept of Clinical Nutrition, University of Göteborg, Sahlgrenska Hospital, Sweden.
Br J Nutr. 1993 Nov;70(3):757-66. doi: 10.1079/bjn19930171.
The effect of addition of sugar-beet fibre to the diet on sterol excretion from the small intestine was studied in nine ileostomy subjects. A constant low-fibre diet was given in two 3 d periods with and without 32 g sugar-beet fibre/d in random order. Care was taken to minimize bacterial alteration of the ileostomy contents. The addition of sugar-beet fibre increased net cholesterol excretion by 52 (SE 9)% (P < 0.01), from 294 (SE 99) to 451 (SE 124) mg/d, and decreased bile acid excretion by 26 (SE 15)% (P < 0.01), from 764 (SE 118) to 567 (SE 96) mg/d. The increased cholesterol and decreased bile acid excretion found with sugar-beet fibre addition is different from the pattern associated with fibre sources such as pectin and oat fibre. The interaction between dietary fibre and sterol metabolism may be mediated, therefore, by different mechanisms depending on the fibre source.
在9名回肠造口术患者中研究了饮食中添加甜菜纤维对小肠甾醇排泄的影响。在两个为期3天的时间段内，以随机顺序分别给予恒定的低纤维饮食，其中一个时间段添加32克/天的甜菜纤维，另一个时间段不添加。注意尽量减少回肠造口内容物的细菌改变。添加甜菜纤维使胆固醇净排泄量增加了52（标准误9）%（P<0.01），从294（标准误99）毫克/天增加到451（标准误124）毫克/天，并使胆汁酸排泄量减少了26（标准误15）%（P<0.01），从764（标准误118）毫克/天减少到567（标准误96）毫克/天。添加甜菜纤维时胆固醇增加和胆汁酸减少的情况与果胶和燕麦纤维等纤维来源相关的模式不同。因此，膳食纤维与甾醇代谢之间的相互作用可能由不同的机制介导，具体取决于纤维来源。
