Sandberg A S, Andersson H, Bosaeus I, Carlsson N G, Hasselblad K, Härröd M
Department of Food Science, Chalmers University of Technology, Göteborg, Sweden.
Am J Clin Nutr. 1994 Nov;60(5):751-6. doi: 10.1093/ajcn/60.5.751.
The effect of alginate on ileostomy excretion of sterols and nutrients was investigated in six ileostomy subjects fed a constant low-fiber diet with or without supplementation with 7.5 g sodium alginate. A mean of 95% of uronic acids derived from the sodium alginate was recovered in the ileostomy contents. Supplementation with alginate increased fat excretion by 140% and decreased bile acids excretion by 12%. Sodium and potassium excretion were significantly increased whereas starch and nitrogen excretion were unchanged. Five of six subjects showed a decreased apparent absorption of iron and manganese with alginate, which, however, was not statistically significant. Absorption of phosphorus, calcium, magnesium, and zinc were unchanged. Almost no digestion of sodium alginate occurs in the stomach and small intestine. The increased fatty acids excretion may be explained by the binding or trapping of fatty acids in the gel matrix formed by alginate, which may also cause a reduced bile flow.
在六名回肠造口术患者中进行了研究，这些患者食用恒定的低纤维饮食，其中部分患者补充7.5克海藻酸钠，以探究海藻酸钠对回肠造口术患者固醇和营养物质排泄的影响。回肠造口术内容物中回收了平均95%源自海藻酸钠的糖醛酸。补充海藻酸钠使脂肪排泄增加了140%，胆汁酸排泄减少了12%。钠和钾的排泄显著增加，而淀粉和氮的排泄未变。六名患者中有五名在补充海藻酸钠后铁和锰的表观吸收率降低，但差异无统计学意义。磷、钙、镁和锌的吸收未变。海藻酸钠在胃和小肠中几乎不发生消化。脂肪酸排泄增加可能是由于脂肪酸在海藻酸钠形成的凝胶基质中被结合或捕获，这也可能导致胆汁流量减少。
