加利西亚和葡萄牙中部人群中HLA DQA1和D1S80（pMCT118）等位基因及基因型的分布

The distribution of HLA DQA1 and D1S80 (pMCT118) alleles and genotypes in the populations of Galicia and central Portugal.

作者信息

Lareu M V, Muñoz I, Pestoni C, Rodriguez M S, Vide C, Carracedo A

机构信息

Institute of Legal Medicine, University of Santiago de Compostela, Spain.

出版信息

Int J Legal Med. 1993;106(3):124-8. doi: 10.1007/BF01225231.

DOI:10.1007/BF01225231

PMID:8117589

Abstract

Two South-West European populations (Galicia and Central Portugal) have been studied for the HLA DQA1 and D1S80 systems. The allele and genotype frequencies found have been compared with other previously published data. The distribution of the observed genotypes is in Hardy-Weinberg equilibrium for both systems. In the D1S80 system, no significant differences were found between both populations, although in the HLA DQA1 system the allele DQA1*0301 is twice as frequent in the Galician population. Other populations that have been compared showed a certain degree of divergence for the HLA DQA1 system. The combined chance of exclusion for both systems is 0.84 in Galicia and 0.85 in Central Portugal, and the combined power of discrimination is 0.993 in the 2 populations studied.

摘要

对两个西南欧人群（加利西亚和葡萄牙中部）进行了HLA DQA1和D1S80系统的研究。将所发现的等位基因和基因型频率与之前发表的其他数据进行了比较。观察到的基因型分布在这两个系统中均符合哈迪-温伯格平衡。在D1S80系统中，两个群体之间未发现显著差异，尽管在HLA DQA1系统中，等位基因DQA1*0301在加利西亚人群中的频率是葡萄牙中部人群的两倍。其他已比较的人群在HLA DQA1系统中表现出一定程度的差异。在加利西亚，这两个系统的联合排除概率为0.84，在葡萄牙中部为0.85，在所研究的两个人群中，联合鉴别力为0.993。