本土巴斯克人中的HLA - DQA1：欧洲DQA1*0201等位基因遗传渐变群的描述。

HLA-DQA1 in autochthonous Basques: description of a genocline for the DQA1*0201 allele in Europe.

作者信息

Iriondo M, Manzano C, de la Rúa C

机构信息

Animali Biologia eta Genetika Saila, Zientzi Fakultatea, Euskal Herriko Unibertsitatea, Leioa, Spain.

出版信息

Int J Legal Med. 1996;109(4):181-5. doi: 10.1007/BF01225516.

DOI:10.1007/BF01225516

PMID:9007633

Abstract

A total of 250 autochthonous Basque individuals were tested in the HLA-DQA1 system, and the allele frequency distribution found was significantly different from that of any other European population. The differences centre mainly on the alleles DQA10201 and DQA10501: for the former the Basques have the highest frequency described anywhere in the world (f = 0.210) and for the latter they have the lowest frequency in Europe (f = 0.204). For the allele DQA1*0201 a genocline is also described in Europe with the Basques and Finno-Ugric populations basically at the extremes. The genocline reflects the isolation of the Basque population since prehistoric times, and supports existing linguistic, archaeological and genetic data.

摘要

共有250名巴斯克本地个体接受了HLA - DQA1系统检测，所发现的等位基因频率分布与任何其他欧洲人群均有显著差异。差异主要集中在等位基因DQA10201和DQA10501上：对于前者，巴斯克人拥有世界上任何地方所描述的最高频率（f = 0.210），而对于后者，他们在欧洲拥有最低频率（f = 0.204）。对于等位基因DQA1*0201，在欧洲也描述了一条基因渐变群，巴斯克人和芬兰 - 乌戈尔人群基本处于两端。这种基因渐变群反映了自史前时代以来巴斯克人群的隔离状态，并支持现有的语言、考古和基因数据。