Sklan D, Dubrov D, Eisner U, Hurwitz S
J Nutr. 1975 Dec;105(12):1549-52. doi: 10.1093/jn/105.12.1549.
The use of 91Y, 51Cr-EDTA, and 141Cr as nonabosrbed reference substances in the gastrointestinal tract of the chick was examined. In single oral dose experiments, more than 95% of the isotopes administered was recovered from the gastrointestinal tract 3 hours after dosing. 51Cr was higher in blood than the other isotopes tested. When the isotopes were fed continuously, the ratio of 91Y to 141Cr changed little throughout the gastrointestinal tract. However, the ratio of 91Y to 51Cr was higher in the crop and gizzard and lower in the duodenum than in the feed. Thus, passage time was shorter for 51Cr in the crop and gizzard and longer in the duodenum than that of 91Y. On the basis of distribution between solid and liquid phases in the intestinal contents, 91Y or 141Ce appears to be a suitable reference substance for studying the absorption of nitrogen and fatty acids, wheras 51Cr-EDTA would be preferable for bile acid absorption studies.
研究了将91Y、51Cr-乙二胺四乙酸（51Cr-EDTA）和141Cr用作雏鸡胃肠道中未吸收参考物质的情况。在单次口服剂量实验中，给药3小时后，超过95%的给药同位素从胃肠道中回收。51Cr在血液中的含量高于其他测试同位素。当连续投喂同位素时，整个胃肠道中91Y与141Cr的比值变化不大。然而，与饲料相比，嗉囊和砂囊中91Y与51Cr的比值较高，十二指肠中该比值较低。因此，51Cr在嗉囊和砂囊中的通过时间比91Y短，在十二指肠中的通过时间比91Y长。基于肠内容物中固液相的分布，91Y或141Ce似乎是研究氮和脂肪酸吸收的合适参考物质，而51Cr-EDTA更适合用于胆汁酸吸收研究。
