Korneev A A, Komissarova I A, Nartsissov Ia R
Biull Eksp Biol Med. 1993 Sep;116(9):261-3.
The antihypoxic effect of glutathione was studied in a pressure chamber of acute hypoxic hypoxia and in the perfused heart of non-inbred rats. The body's natural metabolite glutathione was found to show the properties of an active antihypoxant, a protector of energy action. The mechanism of this action of glutathione may be associated with decreased hyper-recovery of the mitochondrial respiratory chain and with its restored capacity to synthesize ATP at the first point of oxidative phosphorylation.
在急性低氧性缺氧压力舱和非近交系大鼠的灌注心脏中研究了谷胱甘肽的抗缺氧作用。发现机体的天然代谢产物谷胱甘肽具有活性抗缺氧剂的特性,即能量作用的保护剂。谷胱甘肽这种作用的机制可能与线粒体呼吸链过度恢复的降低及其在氧化磷酸化第一点合成ATP的能力恢复有关。