Korneev A A, Komissarova I A
Izv Akad Nauk Ser Biol. 1993 Jul-Aug(4):542-9.
The role of glutathione in metabolic response of the cell to hypoxia is discussed. Experiments were carried on random bred white female rats and their offspring. The antihypoxic effect of glutathione was studied using a low-pressure chamber model of acute hypoxic hypoxia and a perfused heart. When administered during the last third of pregnancy, glutathione stimulates in the female and in the foetus development of protective-adaptive reactions, thus increasing the resistance of hypoxia. This is expressed in an increased resistance to acute hypoxia and an improved mechano-energetic coupling of the myocardium. A proposed mechanism underlying the hypoxic, energizing effect of glutathione is related to decreased hyper-reduction of the NAD-dependent region of the respiratory chain and the recovery of its ability to synthesize ATP in the first site of oxidative phosphorylation. The results obtained allow us to outline perspectives of search for new compounds controlling the level of glutathione in the cells and, hence, activating the development of adaptational compensatory mechanisms for protection against de-energizing effect of hypoxia and similar factors.
本文讨论了谷胱甘肽在细胞对缺氧的代谢反应中的作用。实验选用随机繁殖的白色雌性大鼠及其后代。采用急性低氧性缺氧低压舱模型和离体灌流心脏研究了谷胱甘肽的抗缺氧作用。在妊娠最后三分之一期间给予谷胱甘肽，可刺激雌性大鼠和胎儿保护性适应反应的发展，从而增加对缺氧的抵抗力。这表现为对急性缺氧的抵抗力增强以及心肌机械 - 能量耦合改善。谷胱甘肽的缺氧促能作用的潜在机制可能与呼吸链中依赖NAD区域的过度还原减少以及氧化磷酸化第一个位点合成ATP能力的恢复有关。所得结果使我们能够勾勒出寻找控制细胞内谷胱甘肽水平的新化合物的前景，从而激活适应性补偿机制的发展，以保护细胞免受缺氧和类似因素的去能作用。
