Korneev A A, Komissarova I A, Chirkova E M, Koppel' M A, Popova O A, Sheveleva G A, Filimonov V G
Eksp Klin Farmakol. 1996 Sep-Oct;59(5):31-5.
Individual resistance of pregnant rats and the newborns to acute hypoxic hypoxia was studied. It was found that individual resistance of the organism to hypoxia significantly decreases in the last period of pregnancy. A new drug limontar proved to possess the properties of an active antihypoxia agent. Its administration during the last third of pregnancy stimulated the organism's protective-adaptational reactions, increased the resistance of pregnant, rats and the newborns to hypoxia. Limontar significantly improves the mechanometabolic indices of an isolated perfused heart under hypoxic conditions. Analysis of the obtained data suggests that limontar increases energy formation in the myocardium through activation of a more efficient and energetically beneficial path of succinic acid oxidation.
研究了妊娠大鼠及其新生仔对急性低氧性缺氧的个体抵抗力。结果发现，机体对缺氧的个体抵抗力在妊娠后期显著降低。一种新药利蒙塔尔被证明具有活性抗缺氧剂的特性。在妊娠最后三分之一期间给予该药可刺激机体的保护性适应反应，增强妊娠大鼠及其新生仔对缺氧的抵抗力。利蒙塔尔能显著改善缺氧条件下离体灌流心脏的机械代谢指标。对所得数据的分析表明，利蒙塔尔通过激活更有效且能量效益更高的琥珀酸氧化途径来增加心肌中的能量生成。
