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[X射线和核磁共振造影剂对正常及病理状态下大鼠肾脏脂质过氧化的影响]

[The effect of x-ray and NMR contrast agents on lipid peroxidation in the normal and pathological kidneys of rats].

作者信息

Bolotova E N, Sergeev P V, Shimanovskiĭ N L, Kerimaliev M K

出版信息

Biull Eksp Biol Med. 1993 Sep;116(9):277-9.

PMID:8118002
Abstract

It has been studied in vivo and vitro effects of and NMR contrast media on renal lipid peroxidation in intact rats and animals with experimental pathologies; glycerine nephritis and CCL4 intoxication. The effects of contrast media was dependent on the time of application, their concentration and conditions of elimination organs. The value of contrast media effect was decreased in order: GdCl3, bilignost, triombrast, iogexol, omnipaque. Gd-DTPA did not influence lipid peroxidation in any cases.

摘要

已经研究了体内和体外NMR造影剂对完整大鼠以及患有实验性病变(甘油性肾炎和四氯化碳中毒)动物的肾脏脂质过氧化的影响。造影剂的作用取决于应用时间、其浓度以及排泄器官的状况。造影剂作用的大小依次降低:氯化钆、双香豆素、三溴沙仑、碘克沙醇、欧乃派克。钆喷酸葡胺在任何情况下均不影响脂质过氧化。

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