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氧自由基与急性胰腺炎:事实还是虚构?

Oxygen free radicals and acute pancreatitis: fact or fiction?

作者信息

Creagh T A, Leahy A L, Bouchier-Hayes D J, Tormey W, Leader M, Broe P J

机构信息

Department of Surgery, Beaumont Hospital, Dublin, Ireland.

出版信息

Ir J Med Sci. 1993 Dec;162(12):497-8. doi: 10.1007/BF03022581.

DOI:10.1007/BF03022581
PMID:8119786
Abstract

The effect of oxygen free radical suppression was studied in the taurocholate model of acute pancreatitis in the rat using systemic allopurinol, superoxide dismutase (S.O.D.) and catalase. None of the treatments were beneficial which suggests that oxygen free radical suppression is unlikely to be clinically beneficial in acute pancreatitis.

摘要

使用全身应用别嘌呤醇、超氧化物歧化酶(S.O.D.)和过氧化氢酶,在大鼠牛磺胆酸盐急性胰腺炎模型中研究了氧自由基抑制的作用。这些治疗均无益处,这表明在急性胰腺炎中抑制氧自由基不太可能具有临床益处。

相似文献

1
Oxygen free radicals and acute pancreatitis: fact or fiction?氧自由基与急性胰腺炎:事实还是虚构?
Ir J Med Sci. 1993 Dec;162(12):497-8. doi: 10.1007/BF03022581.
2
Involvement of oxygen-derived free radicals in L-arginine-induced acute pancreatitis.氧衍生自由基在L-精氨酸诱导的急性胰腺炎中的作用。
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Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis.进展性实验性胰腺炎中的自由基抑制与连续化学发光
Br J Surg. 1990 Nov;77(11):1256-9. doi: 10.1002/bjs.1800771119.
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本文引用的文献

1
Experimental pancreatitis in the rat. Sodium taurocholate-induced acute haemorrhagic pancreatitis.大鼠实验性胰腺炎。牛磺胆酸钠诱导的急性出血性胰腺炎。
Scand J Gastroenterol. 1980;15(4):411-6. doi: 10.3109/00365528009181493.
2
Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity.聚乙二醇:超氧化物歧化酶加合物的制备及其血液循环寿命和抗炎活性研究。
Res Commun Chem Pathol Pharmacol. 1980 Jul;29(1):113-27.
3
Organ chemiluminescence: noninvasive assay for oxidative radical reactions.
有机化学发光:氧化自由基反应的非侵入性检测方法。
Proc Natl Acad Sci U S A. 1980 Jan;77(1):347-51. doi: 10.1073/pnas.77.1.347.
4
Experimental gallstone pancreatitis. Pathogenesis and response to different treatment modalities.实验性胆石性胰腺炎。发病机制及对不同治疗方式的反应。
Ann Surg. 1982 May;195(5):566-73. doi: 10.1097/00000658-198205000-00005.
5
Oxygen-derived free radicals and acute pancreatitis: a review.氧衍生自由基与急性胰腺炎:综述
Acta Physiol Scand Suppl. 1986;548:109-18.
6
Pathophysiology of free radical-mediated reperfusion injury.自由基介导的再灌注损伤的病理生理学
J Vasc Surg. 1987 Mar;5(3):512-7.
7
Failure of antioxidant therapy (polyethylene glycol-conjugated catalase) in acute pancreatitis.
Am J Surg. 1989 Jan;157(1):145-9. doi: 10.1016/0002-9610(89)90437-6.
8
The pathogenesis of acute pancreatitis. The source and role of oxygen-derived free radicals in three different experimental models.急性胰腺炎的发病机制。氧衍生自由基在三种不同实验模型中的来源及作用。
Ann Surg. 1985 May;201(5):633-9. doi: 10.1097/00000658-198505000-00013.
9
Superoxide dismutase and catalase: a possible role in established pancreatitis.
Am J Surg. 1986 Jan;151(1):163-9. doi: 10.1016/0002-9610(86)90027-9.
10
Free radical inhibition and serial chemiluminescence in evolving experimental pancreatitis.进展性实验性胰腺炎中的自由基抑制与连续化学发光
Br J Surg. 1990 Nov;77(11):1256-9. doi: 10.1002/bjs.1800771119.