Weber A, Bernt C, Bauer K, Mayr A
Landesuntersuchungsamt für das Gesundheitswesen Nordbayern, Nürnberg.
Tierarztl Prax. 1993 Dec;21(6):511-6.
Data were collected from 39 cattle herds in Northern Bavaria with confirmed outbreaks of salmonellosis and analysed regarding the use of herd-specific Salmonella vaccines in control of this infectious disease. The inactivated vaccine was applied intranasally three times at intervals of 1 week (each dose of 5 ml; concentration of antigen about 10(10) organisms/ml, inactivated by heat at 100 degrees C). Efficacy of vaccine was evaluated by comparing bacteriological examination of fecal shedding of Salmonellae before and after vaccination. The number of Salmonella-positive fecal samples was reduced within one week p. vacc. from 25% to less than 1% of all examined fecal samples. Two thirds (65.7%) of the herds were free of infection within 3 weeks p. vacc. Best results after vaccination were obtained when each animal, including the calves, was vaccinated. Further it could be determined that smaller farms with up to 70 cattle did better than larger farms, where often only a part of the herd was immunized (82.6% and 33.3%).
从巴伐利亚北部39个确诊感染沙门氏菌病的牛群中收集数据，并分析了使用特定牛群的沙门氏菌疫苗控制这种传染病的情况。灭活疫苗通过鼻腔接种，共接种3次，每次间隔1周（每次剂量5毫升；抗原浓度约为10¹⁰个菌/ml，在100℃加热灭活）。通过比较接种疫苗前后粪便中沙门氏菌的细菌学检查来评估疫苗的效力。接种疫苗后1周内，沙门氏菌阳性粪便样本的数量从所有检测粪便样本的25%降至不到1%。三分之二（65.7%）的牛群在接种疫苗后3周内没有感染。当包括犊牛在内的每头动物都接种疫苗时，接种后可获得最佳效果。此外，可以确定，牛数量最多为70头的较小农场比大型农场效果更好，大型农场通常只对部分牛群进行免疫（分别为82.6%和33.3%）。
