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诱导对对氨基苯胂酸偶联的同基因细胞具有特异性的细胞毒性T淋巴细胞。

The induction of cytolytic T lymphocytes with specificity for p-azophenylarsonate coupled syngeneic cells.

作者信息

Sherman L A, Burakoff S J, Benacerraf B

出版信息

J Immunol. 1978 Oct;121(4):1432-6.

PMID:81234
Abstract

Conditions are described for diazonium linkage of the hapten p-azophenylarsonate (Ar) to mouse lymphocytes for the purpose of induction of syngeneic cytolytic T lymphocytes. These cytolytic effector cells do not lyse target cells that are coupled with an unrelated hapten, trinitrophenyl. Cell lysis can be blocked by the addition of anti-Ar antiserum. Only those target cells that share H-2 K or D end antigens with the stimulating cell population are susceptible to lysis. Several methods were used in an attempt to demonstrate the presence of the Ar cross-reactive idiotype on CTL induced in A/J mice.

摘要

描述了将半抗原对氨基苯偶氮胂酸（Ar）与小鼠淋巴细胞进行重氮键连接的条件，目的是诱导同基因溶细胞性T淋巴细胞。这些溶细胞效应细胞不会裂解与无关半抗原三硝基苯偶联的靶细胞。加入抗Ar抗血清可阻断细胞裂解。只有那些与刺激细胞群体共享H-2 K或D端抗原的靶细胞才易被裂解。使用了几种方法试图证明在A/J小鼠中诱导的CTL上存在Ar交叉反应独特型。

相似文献

1
The induction of cytolytic T lymphocytes with specificity for p-azophenylarsonate coupled syngeneic cells.诱导对对氨基苯胂酸偶联的同基因细胞具有特异性的细胞毒性T淋巴细胞。
J Immunol. 1978 Oct;121(4):1432-6.
2
Relationship of idiotypes of the anti-p-azophenylarsonate antibodies of A/J and BALB/c mice.A/J和BALB/c小鼠抗对氨基苯砷酸抗体的独特型关系。
J Immunol. 1981 Apr;126(4):1268-73.
3
Regulation of the hapten-specific T cell response. I. Preferential induction of hyporesponsiveness to the D-end of the major histocompatibility complex in the hapten-specific cytotoxic T cell response.半抗原特异性T细胞应答的调节。I. 在半抗原特异性细胞毒性T细胞应答中对主要组织相容性复合体D端低反应性的优先诱导。
J Immunol. 1983 Nov;131(5):2184-9.
4
An intrastrain cross-reactive idiotype associated with anti-p-azophenylarsonate antibodies of BALB/c mice.与BALB/c小鼠抗对氨基苯胂酸抗体相关的株内交叉反应独特型。
J Immunol. 1981 Apr;126(4):1263-7.
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Idiotypic heterogeneity of the cross-reactive idiotype associated with the anti-p-azophenylarsonate antibodies of BALB/c mice.与BALB/c小鼠抗对氨基苯胂酸抗体相关的交叉反应性独特型的独特型异质性。
J Immunol. 1983 Jul;131(1):423-8.
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Antigen-specific suppression of cytotoxic T cell responses: an idiotype-bearing factor regulates the cytotoxic T cell response to azobenzenearsonate-coupled cells.细胞毒性T细胞反应的抗原特异性抑制：一种携带独特型的因子调节细胞毒性T细胞对偶氮苯砷酸盐偶联细胞的反应。
J Immunol. 1982 Mar;128(3):1188-91.
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In nature of idiotypes associated with anti-p-azophenylarsonate antibodies in A/J mice.关于A/J小鼠中与抗对氨基苯胂酸抗体相关的独特型的性质。
Ann Immunol (Paris). 1979 Mar-Apr;130(2):199-213.
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Naturally occurring cytotoxic T lymphocyte precursors with specificity for an Ig idiotype.对一种免疫球蛋白独特型具有特异性的天然细胞毒性T淋巴细胞前体。
J Immunol. 1988 Dec 1;141(11):3804-9.
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Suppression of anti-hapten antibody responses by hapten-specific cytolytic T lymphocytes: role of I-A-associated antigen on target B lymphocytes.半抗原特异性细胞毒性T淋巴细胞对抗半抗原抗体反应的抑制作用：I-A相关抗原在靶B淋巴细胞上的作用
J Immunol. 1982 Jul;129(1):63-9.
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Presence of an intrastrain cross-reactive idiotype on A/J antibodies of the IgE class specific for the p-azophenylarsonate group.针对对氨基苯砷酸基团的IgE类A/J抗体上存在菌株内交叉反应独特型。
J Immunol. 1983 Mar;130(3):1300-2.

引用本文的文献

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Portrait of an autologous cancer vaccine: Then and now.自体肿瘤疫苗的描绘：过去与现在。
Hum Vaccin Immunother. 2023 Dec 31;19(1):2172925. doi: 10.1080/21645515.2023.2172925. Epub 2023 Feb 8.
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Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte-mediated killing.淋巴细胞功能相关抗原1（LFA-1）：一种与Lyt-2、3不同的表面抗原，参与T淋巴细胞介导的杀伤作用。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4535-9. doi: 10.1073/pnas.78.7.4535.
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Identification of idiotypic receptors on reovirus-specific cytolytic T cells.
呼肠孤病毒特异性溶细胞性T细胞上独特型受体的鉴定
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7479-83. doi: 10.1073/pnas.79.23.7479.
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Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.表达A/J小鼠抗对氨基苯胂酸盐反应主要独特型的杂交瘤蛋白。
Proc Natl Acad Sci U S A. 1980 Feb;77(2):1120-4. doi: 10.1073/pnas.77.2.1120.
5
Recognition and lysis of altered-self cells by macrophages. I. Modification of target cells by 2,4,6-trinitrobenzene sulphonic acid.巨噬细胞对改变自身细胞的识别与裂解。I. 2,4,6-三硝基苯磺酸对靶细胞的修饰
Immunology. 1983 Feb;48(2):265-72.
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Antigen- and receptor-driven regulatory mechanisms. III. Induction of delayed type hypersensitivity to azobenzenearsonate with anti-cross-reactive idiotypic antibodies.抗原和受体驱动的调节机制。III. 用抗交叉反应性独特型抗体诱导对偶氮苯砷酸盐的迟发型超敏反应。
J Exp Med. 1980 Apr 1;151(4):896-909. doi: 10.1084/jem.151.4.896.
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Evidence for the presence of idiotype-bearing regulatory T cells in which idiotype expression does not show linkage to either IgH alleles or the MHC.存在携带独特型的调节性T细胞的证据，其中独特型表达与IgH等位基因或主要组织相容性复合体均无连锁关系。
Immunology. 1984 Apr;51(4):743-54.
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Identification of an I-J+ antigen-presenting cell required for third order suppressor cell activation.鉴定三级抑制细胞激活所需的I-J+抗原呈递细胞。
J Exp Med. 1983 Jan 1;157(1):353-8. doi: 10.1084/jem.157.1.353.
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Two distinct mechanisms regulate the in vivo generation of cytotoxic T cells.两种不同的机制调节细胞毒性T细胞的体内生成。
J Exp Med. 1982 Sep 1;156(3):918-23. doi: 10.1084/jem.156.3.918.
10
Activation specificity of arsonate-reactive T cell clones. Structural requirements for hapten recognition and comparison with monoclonal antibodies.砷酸盐反应性T细胞克隆的激活特异性。半抗原识别的结构要求及与单克隆抗体的比较。
J Exp Med. 1984 Feb 1;159(2):479-94. doi: 10.1084/jem.159.2.479.