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长期抗氧化剂暴露对雌性灵长类动物的影响。

Long-term antioxidant exposure effects on female primates.

作者信息

Allen J R

出版信息

Arch Environ Health. 1976 Jan-Feb;31(1):47-50. doi: 10.1080/00039896.1976.10667189.

DOI:10.1080/00039896.1976.10667189
PMID:812431
Abstract

Butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) were incorporated in the diet of adult rhesus female monkeys at a level that ensured a daily intake of 100 mg/kg of body weight (50 mg of BHA and 50 mg of BHT) for two years. Following the initial year of exposure, during which the monkeys experienced no clinical abnormalities attributable to the antioxidants, they were bred to rhesus males that had received unmodified diets. Their gestation was free of complications and normal infants were delivered naturally. Growth rate, hemograms, and behavior of these infants were similar to those of control infants. The infants and adults were evaluated for two years following the antoxidant exposure. During this period, the adult females continued to have normal infants and the infants born during the exposure period remained heatlhy.

摘要

叔丁基对羟基茴香醚(BHA)和叔丁基对甲酚(BHT)以确保成年雌性恒河猴每日摄入100毫克/千克体重(50毫克BHA和50毫克BHT)的水平添加到其饮食中,持续两年。在最初接触的一年中,猴子未出现任何可归因于抗氧化剂的临床异常情况,之后它们与食用未添加抗氧化剂饮食的雄性恒河猴进行繁殖。它们的妊娠没有并发症,正常分娩出婴儿。这些婴儿的生长速度、血常规和行为与对照婴儿相似。在接触抗氧化剂后,对婴儿和成年猴进行了两年的评估。在此期间,成年雌性继续产下正常婴儿,接触期间出生的婴儿也保持健康。

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