关于大豆脂肪氧合酶-1催化的氧化反应的位置特异性
On the positional specificity of the oxygenation reaction catalysed by soybean lipoxygenase-1.
作者信息
Egmond M R, Veldink G A, Vliegenthart J F, Boldingh J
出版信息
Biochim Biophys Acta. 1975 Dec 17;409(3):399-401. doi: 10.1016/0005-2760(75)90037-5.
PMID:812552
Abstract
Lipoxygenase-1 from soybeans is incubated with an isomer of linoleic acid, 13-cis, 16-cis-octadecadienoic acid. Analysis of the oxygenation products indicates that molecular oxygen is stereospecifically introduced mainly at C-17 (n-2) of the fatty acid (in the LS-configuration), and only to a minor extent at C-13 (n-6). These findings contradict previous suggestions about the postional specificity of lipoxygenase-1.
摘要
将来自大豆的脂氧合酶-1与亚油酸的一种异构体，即13-顺式，16-顺式-十八碳二烯酸一起孵育。对氧化产物的分析表明，分子氧主要以立体特异性方式引入到脂肪酸的C-17（n-2）位（呈LS构型），仅在较小程度上引入到C-13（n-6）位。这些发现与之前关于脂氧合酶-1位置特异性的观点相矛盾。
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