吲哚菁绿引起的不良反应。
Adverse reactions due to indocyanine green.
作者信息
Hope-Ross M, Yannuzzi L A, Gragoudas E S, Guyer D R, Slakter J S, Sorenson J A, Krupsky S, Orlock D A, Puliafito C A
机构信息
LuEsther T. Mertz Retinal Research Laboratory, Manhattan Eye, Ear and Throat Hospital, New York, NY 10021.
出版信息
Ophthalmology. 1994 Mar;101(3):529-33. doi: 10.1016/s0161-6420(94)31303-0.
BACKGROUND
Although adverse reactions to indocyanine green (ICG) are known to occur, the dye has been used for more than 30 years in tests of cardiac and hepatic function, with a high level of safety. Improved digital video technology has renewed interest in the use of intravenous ICG in ophthalmic imaging. This report describes the authors' experience regarding the safety of ICG for digital angiography and their recommendations for its use in the ophthalmic setting.
METHODS
Digital ICG videoangiography was performed in 1226 consecutive patients, and 1923 ICG videoangiography tests were performed. A registry of adverse reactions to ICG was established. Criteria were used to define mild, moderate, and severe adverse reactions, and these data were recorded for every ICG study performed.
RESULTS
There were three (0.15%) mild adverse reactions, four (0.2%) moderate reactions, and one (0.05%) severe adverse reaction. There were no deaths.
CONCLUSIONS
This study documents the safety of intravenous ICG for use in ophthalmic videoangiography.
背景
尽管已知吲哚菁绿（ICG）会引起不良反应，但该染料已在心脏和肝功能检测中使用了30多年，安全性较高。改进后的数字视频技术重新引发了人们对静脉注射ICG用于眼科成像的兴趣。本报告描述了作者关于ICG用于数字血管造影安全性的经验以及他们对其在眼科应用的建议。
方法
对1226例连续患者进行了数字ICG血管造影，并进行了1923次ICG血管造影检查。建立了ICG不良反应登记册。使用标准来定义轻度、中度和重度不良反应，并记录每次ICG研究的这些数据。
结果
有3例（0.15%）轻度不良反应，4例（0.2%）中度反应，1例（0.05%）重度不良反应。无死亡病例。
结论
本研究证明了静脉注射ICG用于眼科视频血管造影的安全性。
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