Lampariello D A, Primo S A
New England College of Optomatry, Boston, Massachusetts 02116, USA.
J Am Optom Assoc. 1997 Jun;68(6):343-52.
Indocyanine green (ICG) is a sterile, water-soluble, tricarbocyanine dye that can be used in fundus angiography as an adjunct to sodium fluorescein. It has a peak spectral absorption of 805 nm in blood plasma or blood, as compared with fluorescein, which has a peak spectral absorption of 465 nm. Because the absorption and emission of ICG lies around 835 nm, transmission of energy by the retinal pigment epithelium (RPE) and serosanguinated material is more efficient in this region than in the region of visible light energy. ICG has the property of being approximately 98% bound to blood protein, disallowing extravasation of excessive dye in the highly fenestrated choroidal vasculature.
The characteristics of ICG are discussed, including administration and dosage, adverse reactions and use of infrared filters for fundus photography. In addition, two cases are presented to illustrate the clinical application of ICG for diagnosis and treatment of choroidal neovascular membranes.
ICG videoangiography can be used to reveal subfoveal choroidal neovascular membranes not previously identified with fluorescein; angiograms can also be used to dramatically highlight retinal and choroidal changes.
The use of ICG for fundus videoangiography provides a more accurate and complete evaluation in certain cases of subretinal and choroidal disease.
吲哚菁绿（ICG）是一种无菌、水溶性的三碳菁染料，可在眼底血管造影中作为荧光素钠的辅助剂使用。与荧光素在血浆或血液中的光谱吸收峰值为465nm相比，ICG在血浆或血液中的光谱吸收峰值为805nm。由于ICG的吸收和发射波长在835nm左右，视网膜色素上皮（RPE）和血性物质在该区域的能量传递比在可见光能量区域更有效。ICG具有约98%与血液蛋白结合的特性，可防止过多染料在高度有窗孔的脉络膜血管系统中渗出。
讨论了ICG的特性，包括给药和剂量、不良反应以及眼底摄影中红外滤光片的使用。此外，还介绍了两个病例，以说明ICG在脉络膜新生血管膜诊断和治疗中的临床应用。
ICG血管造影可用于显示荧光素之前未发现的黄斑下脉络膜新生血管膜；血管造影还可显著突出视网膜和脉络膜的变化。
在某些视网膜下和脉络膜疾病病例中，使用ICG进行眼底血管造影可提供更准确和完整的评估。
