Pileri S, Falini B, Poggi S, Benni M, Bocchia M, Melilli G, Sabattini E, Tazzari P L, Stein H
Istituto di Anatomia e Istologia Patologica e di Ematologia L. & A. Seràgnoli dell'Università di Bologna.
Pathologica. 1993 Sep-Oct;85(1099):445-66.
The Authors critically review the problem of Hodgkin's disease (HD) in the light of the most recent findings obtained by means of immunohistochemistry and molecular biology. The following topics are discussed in details: 1) the definition of the borders between HD and non-Hodgkin's lymphomas, 2) the histogenesis of Hodgkin's and Reed-Sternberg cells, 3) the relationships between neoplastic cells and microenvironment, and 4) the pathogenetic role of Epstein-Barr virus in the onset of HD.
作者根据免疫组织化学和分子生物学的最新研究结果，对霍奇金淋巴瘤（HD）问题进行了批判性综述。详细讨论了以下主题：1）HD与非霍奇金淋巴瘤之间边界的定义；2）霍奇金细胞和里德-斯腾伯格细胞的组织发生；3）肿瘤细胞与微环境之间的关系；4）爱泼斯坦-巴尔病毒在HD发病中的致病作用。
