Genova G, Arena N, Guddo F, Vita C, Reitano R, Nagar C, Tralongo V
Servizio di Anatomia ed Istologia Patologica, Ospedale Villa Sofia, USL 61 Palermo.
Pathologica. 1993 Sep-Oct;85(1099):489-95.
Collagenous colitis is a clinico-pathological entity characterized by chronic diarrhoeas and deposition of collagen beneath the epithelium surface of large bowel. We revised 265 endoscopy biopsy specimens of the large bowel from 198 consecutive patients with "aspecific chronic colitis". Morphometric study showed that were not significant differences among various tracts in the same patients regarding to the thickness of basament membrane. It was more than 11.9 +/- 0.49 mu only in 13 pts (6.6%), while it was 3.96 +/- 1.4 mu in the others. Immunohistochemistry study confirmed the normality of subepithelial basement membrane and the below deposition of the large quantity of collagen IV.
胶原性结肠炎是一种临床病理实体，其特征为慢性腹泻以及大肠上皮表面下胶原沉积。我们回顾了198例“非特异性慢性结肠炎”患者的265份大肠内镜活检标本。形态计量学研究表明，同一患者不同肠段的基底膜厚度无显著差异。仅13例患者（6.6%）的基底膜厚度超过11.9±0.49μm，其他患者的厚度为3.96±1.4μm。免疫组织化学研究证实上皮下基底膜正常，且大量IV型胶原在其下方沉积。
