Mahassin F, Algayres J P, Valmary J, Bili H, Coutant G, Bequet D, Daly J P
Service de Clinique médicale, Hôpital d'Instruction des Armées du Val-de-Grâce, Paris.
Presse Med. 1993 Dec 18;22(40):1997-8.
A 56-year old man was hospitalized for spasmodic paraparesis with sphincter disorders. After exclusion of spinal cord compression and all other inflammatory, infectious or neoplastic causes, the possibility of a connexion with an hepatitis B vaccination performed with a recumbent vaccine three weeks before the neurological disorders appeared was considered. The pathogenesis of such a myelitis remains uncertain. It is based on the possible reactivation of a dormant virus or a crossed antigenic reaction between a protein of the vaccine and the nervous system. The course of the disease is usually favourable. The frequency of this complication would be more accurately determined if all neurological manifestations occurring after hepatitis B vaccination were reported.
一名56岁男性因痉挛性截瘫伴括约肌功能障碍入院。在排除脊髓压迫及所有其他炎症、感染或肿瘤性病因后,考虑到在神经功能障碍出现前三周接种了重组疫苗进行乙肝疫苗接种,有可能与之相关。这种脊髓炎的发病机制尚不确定。其依据可能是潜伏病毒的重新激活或疫苗蛋白与神经系统之间的交叉抗原反应。该病病程通常良好。如果报告所有乙肝疫苗接种后出现的神经学表现,这种并发症的发生率将能更准确地确定。