Schnabel R
Max-Planck-Institut für Biochemie, Martinsried, München, Germany.
Science. 1994 Mar 11;263(5152):1449-52. doi: 10.1126/science.8128230.
EMS, a blastomere of the Caenorhabditis elegans embryo, produces body wall muscle cell-autonomously in isolation. Within the embryonic context, however, the specification of body wall muscle derived from EMS depends on inductive interactions between its daughter MS and ABa descendants that are required to overcome inhibitory interactions with other cells. The inductive events between the MS and ABa descendants are reciprocal, specifying subsequent fates in both lineages. Both induction events are blocked by mutations in the gene glp-1, known to encode a Notch-like transmembrane receptor protein.
EMS是秀丽隐杆线虫胚胎的一个卵裂球，它能自主地单独产生体壁肌肉细胞。然而，在胚胎环境中，源自EMS的体壁肌肉的特化取决于其后代MS和ABa后代之间的诱导相互作用，这种相互作用是克服与其他细胞的抑制性相互作用所必需的。MS和ABa后代之间的诱导事件是相互的，决定了两个谱系中后续的命运。这两个诱导事件都被glp-1基因突变所阻断，已知该基因编码一种Notch样跨膜受体蛋白。
