Mercado-Calderón F
Unidad de Toxicología Industrial, Hospital Central Norte, Petróleos Mexicanos.
Salud Publica Mex. 1993 Nov-Dec;35(6):607-13.
One hundred and twenty-two workers (16 from a coke production plant, 106 from a graphite electrode manufacturing plant) agreed to participate in this study designed to evaluate the relationship between the exposure to polycyclic aromatic hydrocarbons (PAHS) and the urinary excretion of 1-hydroxypyrene (1-HOP), the main metabolite of pyrene. The results show that the concentration of pyrene in air is highly correlated with total PAHS amount (r = 0.083, p < 0.001), with a the correlation coefficient between 1-HOP and total PAHS of r = 0.72 (p < 0.001). The biological half life of the 1-HOP was determined (18 hrs) and the non interference of smoking habits in relation to 1-HOP urinary was established, concluding that 1-HOP is a suitable bioindicator of the occupational exposure to PAHS.
122名工人（16名来自焦炭生产厂，106名来自石墨电极制造厂）同意参与这项旨在评估多环芳烃（PAHs）暴露与芘的主要代谢产物1-羟基芘（1-HOP）尿排泄之间关系的研究。结果表明，空气中芘的浓度与总PAHs量高度相关（r = 0.083，p < 0.001），1-HOP与总PAHs之间的相关系数为r = 0.72（p < 0.001）。确定了1-HOP的生物半衰期（18小时），并确定吸烟习惯对1-HOP尿排泄无干扰，得出结论：1-HOP是职业性PAHs暴露的合适生物标志物。
