既往感染人细小病毒B19对类风湿关节炎易感性的影响：疾病不一致双胞胎对的分析
Influence of previous exposure to human parvovirus B19 infection in explaining susceptibility to rheumatoid arthritis: an analysis of disease discordant twin pairs.
作者信息
Hajeer A H, MacGregor A J, Rigby A S, Ollier W E, Carthy D, Silman A J
机构信息
ARC Epidemiology Research Unit, Manchester University Medical School, United Kingdom.
出版信息
Ann Rheum Dis. 1994 Feb;53(2):137-9. doi: 10.1136/ard.53.2.137.
OBJECTIVES
To assess the association between exposure to parvovirus B19 and susceptibility to rheumatoid arthritis (RA).
METHODS
One hundred and fifty five twin pairs (76 monozygotic (MZ) and 79 dizygotic (DZ)), discordant for RA, were tested for the presence of IgG antiparvovirus antibodies using ELISA. The data obtained were analysed using conditional logistic regression, from which odds ratios and 95% confidence intervals were calculated.
RESULTS
Overall, there was no association between exposure to parvovirus and RA (OR = 1.2, 95% CI: 0.7-1.7). However, in two subgroups there was a suggestion of an association. These were: (1) pairs where the affected twin was rheumatoid factor (RF) seronegative (OR = 2.0, 95% CI: 0.9-12.4) and (2) in opposite-sexed twin pairs where the affected twin was female (OR = 3.0, 95% CI: 0.9-11.6).
CONCLUSION
Previous exposure to parvovirus infection did not explain disease susceptibility in both MZ and DZ discordant pairs with rheumatoid arthritis. This infection, however, might be relevant in some subgroups.
目的
评估接触细小病毒B19与类风湿关节炎（RA）易感性之间的关联。
方法
对155对RA不一致的双胞胎（76对同卵双胞胎（MZ）和79对异卵双胞胎（DZ））进行ELISA检测，以检测IgG抗细小病毒抗体的存在。使用条件逻辑回归分析获得的数据，并计算优势比和95%置信区间。
结果
总体而言，接触细小病毒与RA之间无关联（优势比=1.2，95%置信区间：0.7 - 1.7）。然而，在两个亚组中存在关联迹象。这两个亚组分别是：（1）受影响双胞胎类风湿因子（RF）血清学阴性的双胞胎对（优势比=2.0，95%置信区间：0.9 - 12.4）和（2）受影响双胞胎为女性的异性双胞胎对（优势比=3.0，95%置信区间：0.9 - 11.6）。
结论
在患有类风湿关节炎的MZ和DZ不一致双胞胎对中，既往接触细小病毒感染并不能解释疾病易感性。然而，这种感染可能在某些亚组中具有相关性。
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