类风湿关节炎中糖皮质激素诱导单核白细胞脂皮质素-1的功能受损。
Impaired glucocorticoid induction of mononuclear leukocyte lipocortin-1 in rheumatoid arthritis.
作者信息
Morand E F, Jefferiss C M, Dixey J, Mitra D, Goulding N J
机构信息
Inflammation Research Group, Bath Institute for Rheumatic Diseases, England.
出版信息
Arthritis Rheum. 1994 Feb;37(2):207-11. doi: 10.1002/art.1780370209.
OBJECTIVE
To investigate leukocyte lipocortin-1 production in rheumatoid arthritis (RA).
METHODS
Eight control and 8 RA subjects received 100 mg hydrocortisone intravenously. Leukocyte lipocortin-1 was measured by enzyme-linked immunosorbent assay.
RESULTS
Hydrocortisone induced significant increases in lipocortin-1 production by control mononuclear cells (MNC) (P = 0.006 versus baseline) but not by RA MNC (P = 0.44 versus baseline). Peak lipocortin-1 levels in control MNC were significantly higher than those in RA MNC (P = 0.014).
CONCLUSION
These results indicate that glucocorticoid-induced MNC lipocortin-1 production is impaired in RA.
目的
研究类风湿关节炎（RA）患者白细胞脂皮质素-1的产生情况。
方法
8名对照者和8名RA患者静脉注射100mg氢化可的松。采用酶联免疫吸附测定法检测白细胞脂皮质素-1。
结果
氢化可的松使对照者单核细胞（MNC）的脂皮质素-1产生显著增加（与基线相比，P = 0.006），但RA患者的MNC未增加（与基线相比，P = 0.44）。对照者MNC中脂皮质素-1的峰值水平显著高于RA患者的MNC（P = 0.014）。
结论
这些结果表明，RA患者中糖皮质激素诱导的MNC脂皮质素-1产生受损。
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