神经精神性系统性红斑狼疮中的淋巴细胞抗原。淋巴细胞抗体特异性与临床疾病的关系。

Lymphocyte antigens in neuropsychiatric systemic lupus erythematosus. Relationship of lymphocyte antibody specificities to clinical disease.

作者信息

Denburg S D, Behmann S A, Carbotte R M, Denburg J A

机构信息

Department of Psychiatry, McMaster University, Hamilton, Ontario, Canada.

出版信息

Arthritis Rheum. 1994 Mar;37(3):369-75. doi: 10.1002/art.1780370310.

DOI:10.1002/art.1780370310

PMID:8129792

Abstract

OBJECTIVE

To examine the relationships among specific lymphocyte antigenic reactivities of lupus sera and central nervous system complications of systemic lupus erythematosus (SLE), lymphocytotoxic antibody (LCA) positivity, and specific cognitive impairment.

METHODS

Sera from 115 patients with SLE were examined for the presence of IgM- and IgG-class autoantibodies binding to surface target antigens on lymphocytes, by immunoblotting and microdroplet lymphocytotoxicity studies. Seventy-three of these patients also underwent detailed neuropsychological testing within the same time period.

RESULTS

Significant associations were found between reactivities to several lymphocyte antigenic moieties and neuropsychiatric SLE (NPSLE) or cognitive impairment. Specifically, immunoblot reactivities to 31-32-kd, 50-52-kd, 54-56-kd, and 97-98-kd targets were associated with clinical NPSLE; there was a significant association between reactivity to the 50-52-kd moiety in particular and cognitive impairment. There were also associations between LCA and immunoblot reactivity. Furthermore, the previously reported association between LCA positivity and specific visuospatial cognitive impairment was confirmed with data obtained from 2 different batteries of neuropsychological tests.

CONCLUSION

In some cases, specific antigenic targets of LCA-containing sera may be implicated in the pathogenesis of NPSLE:

摘要

目的

研究狼疮血清中特定淋巴细胞抗原反应性与系统性红斑狼疮（SLE）中枢神经系统并发症、淋巴细胞毒性抗体（LCA）阳性及特定认知障碍之间的关系。

方法

通过免疫印迹和微滴淋巴细胞毒性研究，检测115例SLE患者血清中与淋巴细胞表面靶抗原结合的IgM和IgG类自身抗体。其中73例患者在同一时期还接受了详细的神经心理学测试。

结果

发现对几种淋巴细胞抗原部分的反应性与神经精神性SLE（NPSLE）或认知障碍之间存在显著关联。具体而言，对31 - 32kd、50 - 52kd、54 - 56kd和97 - 98kd靶标的免疫印迹反应性与临床NPSLE相关；特别是对50 - 52kd部分的反应性与认知障碍之间存在显著关联。LCA与免疫印迹反应性之间也存在关联。此外，通过从2种不同的神经心理学测试组获得的数据，证实了先前报道的LCA阳性与特定视觉空间认知障碍之间的关联。