Jaffe L F
Marine Biological Laboratory, Woods Hole, MA.
Cell Calcium. 1993 Nov;14(10):736-45. doi: 10.1016/0143-4160(93)90099-r.
The best known calcium waves move at about 5-30 microns/s (at 20 degrees C) and will be called fast waves to distinguish them from slow (contractile) ones which move at 0.1-1 microns/s as well as electrically propagated, ultrafast ones. Fast waves move deep within cells and seem to underlie most calcium signals. Their velocity and hence mechanism has been remarkably conserved among all or almost all eukaryotic cells. In fully active (but not overstimulated) cells of all sorts, their mean speeds lie between about 15-30 microns/s at 20 degrees C. Their amplitudes usually lie between 3-30 microM and their frequencies from one per 10-300 s. They are propagated by a reaction diffusion mechanism governed by the Luther equation in which Ca2+ ions are the only diffusing propagators, and calcium induced calcium release, or CICR, the only reaction; although this reaction traverses various channels which are generally modulated by IP3 or cADPR. However, they may be generally initiated by a second, lumenal mode of CICR which occurs within the ER. Moreover, they are propagated between cells by a variety of mechanisms. Slow intracellular waves, on the other hand, may be mechanically propagated via stretch sensitive calcium channels.
最为人所知的钙波以约5 - 30微米/秒的速度移动（20摄氏度时），将其称为快波以区别于慢（收缩性）钙波，慢钙波移动速度为0.1 - 1微米/秒，还有电传播的超快钙波。快波在细胞内深部移动，似乎是大多数钙信号的基础。其速度以及相应机制在所有或几乎所有真核细胞中都得到了显著保留。在各类完全活跃（但不过度刺激）的细胞中，20摄氏度时它们的平均速度在约15 - 30微米/秒之间。其振幅通常在3 - 30微摩尔之间，频率为每10 - 300秒一次。它们通过由路德方程控制的反应扩散机制传播，其中Ca2 +离子是唯一扩散的传播者，钙诱导钙释放（CICR）是唯一的反应；尽管此反应通过各种通常由IP3或cADPR调节的通道。然而，它们通常可能由在内质网内发生的第二种腔内CICR模式引发。此外，它们通过多种机制在细胞间传播。另一方面，缓慢的细胞内波可能通过对拉伸敏感的钙通道进行机械传播。
