脾集落形成病毒弗氏株翻译产物的分析
Analysis of translational products of Friend strain of spleen focus-forming virus.
作者信息
Barbacid M, Troxler D H, Scolnick E M, Aaronson S A
出版信息
J Virol. 1978 Sep;27(3):826-30. doi: 10.1128/JVI.27.3.826-830.1978.
Abstract
We have analyzed normal rat kidney cells nonproductively infected with the Friend strain of spleen focus-forming virus (SFFV) for the presence of murine leukemia virus-specific type C viral proteins. SFFV was found to code for the p15 and p12 proteins of Friend-murine leukemia virus as determined by immunological typing of their antigenic determinants. Molecular-size analysis of p15 and p12 proteins in SFFV nonproductively infected normal rat kidney cells indicated that these proteins are translated as parts of polyprotein molecules. The apparent molecular weights of the polypeptides bearing p12 antigenic determinants revealed the presence of translational products of the SFFV genome that could not be accounted for by know type C virus helper structural proteins.
摘要
我们分析了用脾集落形成病毒（SFFV）的弗瑞德株非生产性感染的正常大鼠肾细胞，以检测鼠白血病病毒特异性C型病毒蛋白的存在。通过对其抗原决定簇进行免疫分型，发现SFFV编码弗瑞德-鼠白血病病毒的p15和p12蛋白。对SFFV非生产性感染的正常大鼠肾细胞中的p15和p12蛋白进行分子大小分析表明，这些蛋白是作为多蛋白分子的一部分被翻译的。带有p12抗原决定簇的多肽的表观分子量揭示了SFFV基因组的翻译产物的存在，而这些产物无法用已知的C型病毒辅助结构蛋白来解释。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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TYPING OF MOUSE LEUKAEMIAS BY SEROLOGICAL METHODS.用血清学方法对小鼠白血病进行分型
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