非生产性细胞和S+L-转化细胞中鼠肉瘤病毒的比较。
Comparison of murine sarcoma viruses in nonproducer and S + L - -transformed cells.
作者信息
Aaronson S A, Bassin R H, Weaver C
出版信息
J Virol. 1972 Apr;9(4):701-4. doi: 10.1128/JVI.9.4.701-704.1972.
Abstract
The biologic properties of murine sarcoma viruses in nonproducer and S(+)L(-) cells were compared. Each virus was found to be genetically stable through at least two cycles of rescue and transmission to new cells. There was no evidence for production of a defective murine leukemia virus by S(+)L(-) cells. The results are most consistent with the hypothesis that the sarcoma genome in S(+)L(-) cells contains information for replication functions which the virus in nonproducer cells either lacks or does not express.
摘要
比较了鼠肉瘤病毒在非生产性细胞和S(+)L(-)细胞中的生物学特性。发现每种病毒在至少两个拯救和传播至新细胞的周期中基因稳定。没有证据表明S(+)L(-)细胞产生有缺陷的鼠白血病病毒。这些结果与以下假设最为一致：S(+)L(-)细胞中的肉瘤基因组包含非生产性细胞中的病毒所缺乏或不表达的复制功能信息。
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