比较两种血清肿瘤标志物在乳腺癌中可靠性的简易方法。
Simple method for comparing reliability of two serum tumour markers in breast carcinoma.
作者信息
O'Brien D P, Gough D B, Skehill R, Grimes H, Given H F
机构信息
Department of Surgery, University College Hospital, Galway, Eire.
出版信息
J Clin Pathol. 1994 Feb;47(2):134-7. doi: 10.1136/jcp.47.2.134.
AIMS
To compare the two breast tumour markers, CA15-3 and mucinous-like carcinoma associated antigen (MCA), using Receiver Operating Characteristic (ROC) curve analysis.
METHODS
One hundred and ninety six patients "presenting" with breast carcinoma had serum CA15-3 and MCA concentrations measured.
RESULTS
Using these markers as indicators of stage IV disease at the recommended laboratory level, true positive rates (TPR) and false positive rates (FPR) were obtained as follows: CA15-3 TPR = 75%, FPR = 7.4%, MCA TPR = 80%, FPR = 59.1%. By increasing the CA15-3 cutoff level to 45 U/ml, a TPR and FPR of 75% and 0.6%, respectively were obtained. By increasing the MCA cutoff level to 23 U/ml, a TPR and FPR of 65% and 2.3%, respectively, were obtained.
CONCLUSIONS
Using ROC curve analysis shows that CA15-3 is a superior indicator of metastatic breast disease than MCA at recommended laboratory levels, and by altering the cutoff points, the specificity and sensitivity for both these markers can be improved.
目的
采用受试者工作特征（ROC）曲线分析比较两种乳腺肿瘤标志物CA15 - 3和黏液样癌相关抗原（MCA）。
方法
对196例“患有”乳腺癌的患者测定血清CA15 - 3和MCA浓度。
结果
将这些标志物作为推荐实验室水平下IV期疾病的指标，获得的真阳性率（TPR）和假阳性率（FPR）如下：CA15 - 3的TPR = 75%，FPR = 7.4%；MCA的TPR = 80%，FPR = 59.1%。将CA15 - 3的临界值提高到45 U/ml时，TPR和FPR分别为75%和0.6%。将MCA的临界值提高到23 U/ml时，TPR和FPR分别为65%和2.3%。
结论
采用ROC曲线分析表明，在推荐实验室水平下，CA15 - 3是比MCA更好的转移性乳腺疾病指标，通过改变临界值，这两种标志物的特异性和敏感性均可得到提高。
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