Dencker L, Lindquist N G
Arch Otolaryngol. 1975 Mar;101(3):185-8. doi: 10.1001/archotol.1975.00780320043010.
Autoradiography of the inner ear was performed at varying intervals following intravenous injection of either chloroquine tagged with carbon 14 (14C), or an iodine 125 (125l)-labeled analogue of chloroquine, in rats. In pigmented rats a strong accumulation and retention was noted in the melanin-bearing tissues. In the inner ear there was a very high concentration in the melanin-containing tissues, eg, the stria vascularis and the planum semilunatum. A strong retention was found in these structures 13 days after injection. Accumulation was not observed in the endolymph nor in the perilymph. No accumulation was found in the inner ear of an albino rat. The ototoxic effects of chloroquine may be caused by an accumulation of the drug in the melanin-containing structures in the inner ear, leading to pathological changes in these tissues and secondary lesions in the receptor cells.
在给大鼠静脉注射用碳14（14C）标记的氯喹或碘125（125I）标记的氯喹类似物后，于不同时间间隔对其内耳进行放射自显影。在有色大鼠中，发现含黑色素的组织有强烈的积聚和滞留现象。在内耳，含黑色素的组织，如血管纹和半月形平面，有非常高的浓度。注射后13天在这些结构中发现有强烈的滞留。在内淋巴和外淋巴中未观察到积聚现象。在白化大鼠的内耳中未发现积聚。氯喹的耳毒性作用可能是由于药物在内耳含黑色素的结构中积聚，导致这些组织发生病理变化以及受体细胞发生继发性病变。
