Redl K, Breu W, Davis B, Bauer R
Institut für Pharmazeutische Biologie, Universität München, Federal Republic of Germany.
Planta Med. 1994 Feb;60(1):58-62. doi: 10.1055/s-2006-959409.
The n-hexane extract of Bidens campylotheca Schultz Bip. ssp campylotheca (Compositae) showed significant in vitro inhibition of cyclooxygenase (CO) and 5-lipoxygenase (5-LO). Five polyacetylenes, heptadeca-2E,8E,10E,16-tetraene-4,6-diyne (1), heptadeca-2E,8Z,10E,16-tetraene-4,6-diyne (2), heptadeca-2E,8E,16-triene-4,6-diyne-10-ol (3), safynol (5) and, as a new compound, safynol-2-O-isobutyrate (4) could be isolated and their structures elucidated mainly by UV, MS, NMR, and COSY-NMR. The isolated compounds exhibited a significant inhibitory effect on cyclooxygenase and 5-lipoxygenase.
弯苞鬼针草（菊科，弯苞鬼针草亚种）的正己烷提取物在体外对环氧化酶（CO）和5-脂氧合酶（5-LO）表现出显著抑制作用。从中分离出5种聚乙炔类化合物，分别为十七碳-2E,8E,10E,16-四烯-4,6-二炔（1）、十七碳-2E,8Z,10E,16-四烯-4,6-二炔（2）、十七碳-2E,8E,16-三烯-4,6-二炔-10-醇（3）、赛弗诺醇（5），以及一种新化合物赛弗诺醇-2-O-异丁酸酯（4），其结构主要通过紫外光谱、质谱、核磁共振和同核位移相关谱进行解析。分离得到的化合物对环氧化酶和5-脂氧合酶均表现出显著抑制作用。
