Aronen H J, Gazit I E, Louis D N, Buchbinder B R, Pardo F S, Weisskoff R M, Harsh G R, Cosgrove G R, Halpern E F, Hochberg F H
Department of Radiology, Massachusetts General Hospital, Charlestown 02129.
Radiology. 1994 Apr;191(1):41-51. doi: 10.1148/radiology.191.1.8134596.
To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in the evaluation of gliomas.
CBV maps from 19 patients with histologically proved gliomas were calculated from dynamic MR image sets acquired with echo-planar spin-echo imaging after intravenous injection of gadolinium-based contrast material.
The maximum CBV varied from 0.82 to 5.40 in the high-grade group (n = 13) and from 1.01 to 1.21 in the low-grade group (n = 6). The difference was statistically significant. Maximum CBV was associated with mitotic activity and vascularity, but not with cellular atypia, endothelial proliferation, necrosis, or cellularity.
MR CBV maps provided diagnostic information not available with conventional MR imaging in six cases and offers a functional parameter for assessing glioma grade and regions of focal activity.
评估磁共振（MR）脑血容量（CBV）图在胶质瘤评估中的效用。
对19例经组织学证实为胶质瘤的患者，在静脉注射钆基对比剂后，通过回波平面自旋回波成像获得的动态MR图像集计算CBV图。
高级别组（n = 13）的最大CBV在0.82至5.40之间，低级别组（n = 6）的最大CBV在1.01至1.21之间。差异具有统计学意义。最大CBV与有丝分裂活性和血管形成相关，但与细胞异型性、内皮细胞增殖、坏死或细胞密度无关。
MR CBV图在6例患者中提供了传统MR成像无法获得的诊断信息，并为评估胶质瘤分级和局灶性活动区域提供了一个功能参数。
