Chen J R, Yen J H, Lin C C, Tsai W J, Liu W J, Tsai J J, Lin S F, Liu H W
Department of Internal Medicine, School of Medicine, Kaohsiung Medical College, Taiwan.
Am J Chin Med. 1993;21(3-4):257-62. doi: 10.1142/S0192415X93000303.
Systemic lupus erythematosus (SLE) is an important autoimmune disease with multiple organ system involvement. From preliminary studies, we have found that six Chinese herbs: Atractylodes ovata, Anqelica sinensis, Cordyceps sinensis, Liqustrum lucidum, Codonopsis pilosula and Homo sapiens can improve defective in vitro interleukin-2 (IL-2) production in patients with SLE. In order to investigate the in vivo effects of these herbs, we used NZB/NZW F1 mice, a typical lupus animal model used to test these herbs. It was found that C. pilosula, H. sapiens and C. sinensis could prolong the life span of female NZB/NZW F1 mice and inhibited anti-ds DNA production. Although A. sinensis could prolong the life span of experimental mice, it did not inhibit the production of anti-ds DNA antibody. These herbs may have great potential for the management of human SLE in the future.
系统性红斑狼疮（SLE）是一种累及多器官系统的重要自身免疫性疾病。通过初步研究，我们发现六种中药：白术、当归、冬虫夏草、女贞子、党参和人（此处“人”作为药材名存疑，原文可能有误）可改善SLE患者体外白细胞介素-2（IL-2）产生缺陷的情况。为了研究这些中药的体内作用，我们使用了NZB/NZW F1小鼠，这是一种用于测试这些中药的典型狼疮动物模型。结果发现，党参、人（此处“人”作为药材名存疑，原文可能有误）和冬虫夏草可延长雌性NZB/NZW F1小鼠的寿命，并抑制抗双链DNA的产生。虽然当归可延长实验小鼠的寿命，但它并未抑制抗双链DNA抗体的产生。这些中药未来可能在人类SLE的治疗中具有巨大潜力。
