Kolosovsky E D
Dermatovenereology Department, St. Petersburg's Institute of Advanced Medical Studies, S.M. Kirov, Russia.
Dermatology. 1994;188(2):140-1. doi: 10.1159/000247119.
158 patients with different forms of psoriasis were examined for the content of kallikrein and kallikreinogen in blood plasma and treated by different preparations including andecalin and dilminal-D. Changes in the kallikrein-kinin system may play a role in the development of psoriasis. The aim of this study was to investigate the relationship of changes in the kallikrein-kinin system induced by andecalin and dilminal-D and the clinical course of psoriasis. Determination of kallikrein and kallikreinogen content in blood plasma was made according to the methods of Paskhina and Krynskaya. Almost all psoriatic patients showed high kallikrein and kallikreinogen levels in blood plasma. We conclude that changes in the kallikrein-kinin system are involved in the pathogenesis of psoriasis. Andecalin and dilminal-D preparations resulted in a marked amelioration of psoriasis.
对158例不同类型银屑病患者的血浆激肽释放酶和激肽原含量进行了检测，并使用包括安得卡林和地尔米纳尔-D在内的不同制剂进行治疗。激肽释放酶-激肽系统的变化可能在银屑病的发生发展中起作用。本研究的目的是探讨安得卡林和地尔米纳尔-D诱导的激肽释放酶-激肽系统变化与银屑病临床病程之间的关系。根据帕什基娜和克林斯卡娅的方法测定血浆中激肽释放酶和激肽原的含量。几乎所有银屑病患者血浆中的激肽释放酶和激肽原水平都很高。我们得出结论，激肽释放酶-激肽系统的变化参与了银屑病的发病机制。安得卡林和地尔米纳尔-D制剂使银屑病有明显改善。
