Runge M S
University of Texas Medical Branch, Galveston 77555, USA.
Trans Am Clin Climatol Assoc. 1999;110:119-29; discussion 129-30.
Numerous lines of investigation support the importance of oxidative stress in the development of atherosclerosis. Results from studies in isolated cells and in animal models of atherosclerosis are compelling, as are those from a select number of clinical trials. Unfortunately, the results of prospective, randomized clinical studies have been disappointing and may reflect our current inability to accurately assess oxidative risk and the response to antioxidant therapy. Only when it is possible to accurately and easily measure oxidative stress will it be possible to accurately determine the efficacy of different antioxidant approaches.
众多研究方向都支持氧化应激在动脉粥样硬化发展过程中的重要性。在分离细胞和动脉粥样硬化动物模型中的研究结果令人信服，一些临床试验的结果也是如此。不幸的是，前瞻性随机临床研究的结果并不理想，这可能反映出我们目前无法准确评估氧化风险以及对抗氧化治疗的反应。只有当能够准确且轻松地测量氧化应激时，才有可能准确确定不同抗氧化方法的疗效。
