Kontush A, Hübner C, Finckh B, Kohlschütter A, Beisiegel U
Medizinische Klinik, Universitätskrankenhaus Eppendorf, Hamburg, Germany.
FEBS Lett. 1994 Mar 14;341(1):69-73. doi: 10.1016/0014-5793(94)80242-4.
At an early stage of oxidation induced by Cu2+, the rate of oxidative modification of human low density lipoprotein (LDL) from healthy donors correlated negatively to its ubiquinol-10 (r = -0.58, P < 0.01) and positively to its polyunsaturated fatty acid (PUFA) (r = 0.53, P < 0.05) content. The PUFA/ubiquinol-10 ratio was the best predictor of LDL susceptibility to oxidation (r = 0.68, P < 0.01). No significant correlation between LDL oxidizability and its alpha-tocopherol content was found at any oxidation stage. It is suggested that ubiquinol-10 plays a central role in the early protection of LDL PUFAs against Cu(2+)-induced oxidation whereas alpha-tocopherol posesses both pro- and antioxidant activity.
