人血清中和Vero细胞毒素VT1、VT2及VT2变异体活性的能力。

Ability of human sera to neutralise the activity of Vero cytotoxins VT1, VT2 and variant forms of VT2.

作者信息

Scotland S M, Said B, Thomas A, Rowe B

机构信息

Laboratory of Enteric Pathogens, Central Public Health Laboratory, London, UK.

出版信息

FEMS Microbiol Lett. 1994 Jan 15;115(2-3):285-9. doi: 10.1111/j.1574-6968.1994.tb06652.x.

DOI:10.1111/j.1574-6968.1994.tb06652.x

PMID:8138140

Abstract

Sera, from 17 patients with diarrhoea or haemolytic uraemic syndrome, and six healthy adults, were tested for neutralisation of Vero cytotoxins (VT). For all 17 patients there was evidence of infection with Escherichia coli O157. Sera from two controls but from none of the patients neutralised VT1, although two patients were infected by strains producing VT1 and VT2. Sera from all six controls and 14 patients neutralised VT2 derived from strains 933 and E32511, but not variant forms of VT2 derived from strains E32511, E57, B2F1 and H.1.8. This neutralising activity warrants further investigation, especially as many O157 VTEC carry both VT2 and VT2 variant genes.

摘要

对17名腹泻或溶血尿毒综合征患者以及6名健康成年人的血清进行了Vero细胞毒素（VT）中和检测。在所有17名患者中，均有感染大肠杆菌O157的证据。两名对照者的血清能中和VT1，但患者中无人能中和，尽管有两名患者感染了产VT1和VT2的菌株。所有6名对照者和14名患者的血清能中和源自933和E32511菌株的VT2，但不能中和源自E32511、E57、B2F1和H.1.8菌株的VT2变异形式。这种中和活性值得进一步研究，特别是因为许多O157 VTEC携带VT2和VT2变异基因。