Atroshchenko E S, Karpova I S
Kardiologiia. 1993;33(10):23-5, 4.
A comparison of the efficacy of treating two patient group (Group 1, patients receiving nitrates in combination with parmidin and Group 2, those taking nitrates) revealed that the two groups did not differ greatly in the clinical effects. In heart failure patients with high capillary permeability, parmidin substantially decreased the permeability to protein, which was associated with decreases in the baseline high activity of primary lipid peroxidation product in plasma red blood cells, which was not observed in the controls. At the same time parmidin was demonstrated to exert an unfavourable effect on microhemocirculation and to increase the patient's autosensibilisation.
对两组患者（第1组，接受硝酸盐与双嘧达莫联合治疗的患者；第2组，服用硝酸盐的患者）进行治疗效果比较，结果显示两组的临床效果差异不大。在毛细血管通透性高的心力衰竭患者中，双嘧达莫可显著降低蛋白质通透性，这与血浆红细胞中初级脂质过氧化产物基线高活性的降低相关，而在对照组中未观察到这种情况。与此同时，双嘧达莫被证明对微循环有不利影响，并增加患者的自身致敏作用。
