Catanzarite V, Dankner W M
Sharp Memorial Hospital Women's Center, San Diego, California.
Prenat Diagn. 1993 Nov;13(11):1021-5. doi: 10.1002/pd.1970131103.
Cytomegalovirus (CMV) is the most common cause of congenital infection. Recent studies show amniocentesis to be a 100 per cent sensitive and 100 per cent specific predictor of congenital infection, and recommend that it be offered in the at-risk pregnancy. However, these publications have focused on pregnancies at or beyond 22 weeks' gestation. Here, we report a case of maternal CMV hepatitis at 7-8 weeks' gestation, in which culture and polymerase chain reaction testing for CMV in amniotic fluid at 20 weeks' gestation were negative, but the infant had a positive CMV urine culture shortly after delivery. Implications for the prenatal diagnosis of CMV infection are discussed.
巨细胞病毒（CMV）是先天性感染最常见的病因。最近的研究表明，羊水穿刺术对先天性感染的预测具有100%的敏感性和100%的特异性，并建议在高危妊娠中进行该项检查。然而，这些出版物关注的是妊娠22周及以后的情况。在此，我们报告一例妊娠7 - 8周时发生的母体CMV肝炎病例，该病例在妊娠20周时羊水CMV培养和聚合酶链反应检测均为阴性，但婴儿在出生后不久CMV尿液培养呈阳性。文中讨论了其对CMV感染产前诊断的意义。
